Endocrine Abstracts

Background: The gestational diabetes mellitus (GDM) is a metabolic disorder characterized by glucose intolerance in pregnant women without pre-existing diabetes, typically diagnosed in mid to late pregnancy. The global prevalence of GDM is on the rise, posing significant diagnostic and economic burdens on society and affecting the health of two generations, potentially impacting population quality. Early diagnosis or understanding of the pathophysiology of this disease in earl...

Background: The 5-year survival rate for patients with unresectable, metastatic pancreatic neuroendocrine tumors (pNETs) remains less than 30%, emphasizing the need for new and effective treatment options for patients with advanced pNETs. Notch1 signaling is a critical cell-cell communication pathway responsible for regulating differentiation, cell fate determination, and epithelial-mesenchymal transition (EMT). Notch1 plays a critical role in the differentiation state of NE c...

Background: Insulin-like growth factor 1 (IGF1) has molecular structure similar to insulin. As an important mediator of growth hormone, IGF-1 plays roles in growth of children and anabolic effects of adults. We evaluate serum levels of IGF-1 in patients with hyperthyroidism or euthyroidism.Subjects and methods: In this study, 30 patients with hyperthyroidism (HY group) and 30 euthyroid individuals (EU group) were recruited. The patients of HY group were ...

Background: Hyperuricemia is often associated with chronic kidney diseases (CKD) and is considered as an independent risk factor of cardiovascular and renal diseases. Urate transporter 1 (URAT1), organic anion transporter 1 (OAT1) and OAT3 are believed to play pivotal roles on urate excretion in kidneys. Activation of RAAS in the kidney plays a key role in the pathophysiology of CKD. Thus, we hypothesized that RAAS may be involved in hyperuricemia in patients with CKD by effec...

Background: The 5-year survival rate for patients with advanced pancreatic neuroendocrine tumors (pNETs) is less than 30%. Notch signaling is a transmembrane receptor pathway with four distinct isoforms, activation of which is linked to cellular differentiation, cell fate, and viability. Both Notch1 and Notch3 signaling have been shown to be dysregulated in pNETs. Notch3 activation has been shown to repress Notch1 activity in other cancers. We hypothesize that activation of No...

Background: Handgrip strength (HGS) and skeletal muscle mass (SMM) are associated with all-cause and cardiovascular disease (CVD)-specific mortality risk in type 2 diabetes (T2DM) patients. However, the pattern of this association was unclear. We aimed to explore the pattern of associations between HGS and SMM with all-cause and CVD mortality risk in a diabetic population.Method: Data were obtained from the UK Biobank (application number 92014), a large ...

Journal of Endocrinology, 2018, 237(2): 139–152 (DOI: https://doi.org/10.1530/JOE-17-0727)...

Background: Hospital physicians are indoor workers, with higher prevalence of vitamin D deficiency as compared to community-based physicians. The correlation between vitamin D deficiency and osteoporosis later in life has not been fully studied, and bone mineral density (BMD) in elderly hospital physicians has not been systematically examined.Methods: A cross-sectional study measuring BMD in hospital male physicians aged 65 and older was carried out. BMD...

Sixty six year old gentleman was referred to clinic with hypercalcaemia. He suffered with low mood, “funny turns”, nocturia and loose stools with urgency to open bowels. He appeared tanned but no increase pigmentation in skin folds. There was no palpable lymphadenopathy or neck lump. The calcium levels were around three with low normal PTH of 3.7 (2.8 on repeat). He had not developed any complications like osteoporosis, fracture or renal stones secondary to hypercalc...

The gonadotrophin receptors, luteinising hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) are G-protein coupled receptors, vital in regulating reproductive functions. Whilst FSHR and LHR are known to form homomers, and have been recently shown to heterodimerise/oligomerise, the functional and physiological significance of LHR/FSHR heteromerisation remains elusive. This study aimed to explore the functional significance of LHR/FSHR crosstalk, exploring me...